Overall feel we will be going for will be way different from what you will have in the base Core Box. We have a lot of cool ideas how to get Insanity cards in a way, that it will be an additional layer of you not trusting your friends - not only because of their objective but perhaps because of the Insanity cards.
Additionally, interaction with Voidseeders will be way different, you will need to think very carefully where to move or place your hero to not go insane.